Revolution (selamectin) is a simple monthly topical medication demonstrated safe to protect your dog or cat from heartworm disease, fleas, and ear mites. Revolution is also used on dogs for the treatment or prevention of the American Dog Tick, and canine sarcoptic mange. For cats it is also used to treat or prevent hookworms, and roundworms. Revolution requires a prescription from your veterinarian.

What are the possible side effects of Revolution?

The most common side effects include hair loss at the site of application with or without inflammation (redness, flaking) and gastrointestinal upset. See important safety information and full prescribing information, or speak to your vet for further information regarding possible side effects.

How does Revolution work?

Just one dose a month applied at the base of the neck in front of the shoulder blades is all your pet needs for protection against fleas, heartworm disease and other parasites. No pills. No sticky sprays. No more hassling with multiple products. After application, Revolution enters the bloodstream through the skin. Concentrations of Revolution in the blood and tissues prevent heartworm disease. Revolution selectively redistributes from the blood to the skin, where it provides protection against common parasites.

How can I decide which pest protection is best for my pet?

Parasites are an annoying fact of life for our pets. Parasites can cause a range of problems, from bothersome scratching to more serious medical issues, such as infections and dangerous or even deadly diseases. How dangerous these problems are depends on the type of parasite, the degree of infection or infestation, and your pet’s reaction to the parasite. Some parasites that affect dogs and cats also pose a disease risk to humans. Talk to your veterinarian about preventing these parasites and reducing their risks to your dog or cat.

How do I apply Revolution to my pet?

Revolution is a simple-to-apply, quick-drying, small-volume, monthly topical solution—so there’s no need to hassle with larger volume topicals or giving your pet a pill!

What if I'm late giving a Revolution dose?

Give the missed dose as soon as you remember, then one month later continue with monthly doses as usual. Do not give a double dose of the medication.

What should I discuss with my veterinarian before using Revolution?

Tell your veterinarian if your pet has ever had an allergic reaction to the medication.

What is the different between Revolution and Revolution Plus?

Revolution Plus (selamectin and sarolaner topical solution) is for cats only. Revolution (selamectin) is for dogs and cats. Revolution Plus adds to the spectrum of parasites covered for cats, by also protecting against ticks, and providing dual action against fleas and ear mites.

Trusted by Vets to Protect Dogs and Cats From Harmful Parasites for Over 20 Years

Revolution provides broad coverage in one simple, monthly topical application.

Protects dogs against fleas, ticks*, ear mites, heartworm disease, and sarcoptic mites.
Protects cats against fleas, ear mites, heartworm disease, roundworms, and hookworms.

Revolution is available from select retailers and vets with a valid prescription.

Find a Vet Near You

One Simple Application, Once a Month

Unlike some other brands, Revolution does not require gloves to apply, or separation time after application.
Simply wash your hands after applying and continue spending time with your pet as usual.
One monthly dose protects pets against common parasites.
Demonstrated safe for dogs at least 6 weeks of age, and for cats at least 8 weeks of age.

Illustration of a dog and cat in front of a calendar.

Keep Up Your Dog or Cat’s Pest Defense With Worry-Free Reminders

It’s important to apply Revolution at the same time every month to keep your pet protected. Stay on track with our monthly text or email reminders.

Why Your Pets Need Parasite Protection

Parasites are not just “outdoor-only.” Any dog or cat could come in contact with harmful pests at any time of year.

Revolution is demonstrated safe for dogs as young as 6 weeks of age, and cats as young as 8 weeks of age.

Fleas

Fleas can quickly infest your home

They can make their way indoors on your dog or cat, other pets or creatures, on shoes and clothes, or get inside through doors and windows.
Tapeworms and fleas tend to go hand in hand. Fleas can often host tapeworms — and then give them to your pet. Keeping your pet protected from fleas helps reduce their risk from tapeworms too.¹
Flea bites can cause intense itching and allergies. This scratching can lead to hair loss and uncomfortable skin irritations.¹

Ticks (dogs only)

Ticks are found year-round, in every part of the U.S.²

Keeping your dog safe from ticks is important. Even if you avoid wooded areas and carefully check your dog after being outside, it's still easy to miss ticks that may have crawled under the fur or in the ears.
They can cause skin irritation and allergic reactions^2,3

Ear Mites

Ear mites can cause severe skin issues including:⁴

Irritated, red, itchy, and painful ears
Dark brown discharge in the ears
Inflamed ears that could lead to rash or other skin reactions
Damage to the ears caused by excessive scratching
Transmission to other cats and pets through direct contact

Heartworms

Heartworm disease isn’t just serious—it can be fatal^5,6

Just 1 bite from an infected mosquito can give your dog or cat

heartworms.⁷ If left untreated, heartworm disease will eventually cause:

Severe lung issues and breathing difficulty
Damage to other organs, like the liver and kidneys
Heart failure, in extreme cases

Sarcoptic Mites

Sarcoptic mites are easily spread

If left untreated in dogs, these mites cause a skin disease referred to as sarcoptic mange, also know as scabies. Signs of an infection include:

Intense itching, scratching, and biting around the ears and elbows
Red bumps, reddened or inflamed skin
Crusty scabs or scales that can spread to larger areas of the skin
Hair loss

Roundworms

Why should I care about roundworms?

Roundworms get into your home—and into your cat— through contaminated soil, the dirt on your shoes, or infected prey like rodents or bugs^8,9
Major roundworm infections in cats can cause vomiting, weight loss, hair changes and a potbellied appearance^8,9

Hookworms

Why should I care about hookworms?

Hookworms can cause anemia, weight loss, and diarrhea in infected cats¹⁰
Severe hookworm infections can be fatal, especially in kittens¹⁰

Vet-Approved Resources

Discover More Pest Preventatives from Zoetis

Revolution FAQ

: What is Revolution?
Revolution (selamectin) is a simple monthly topical medication demonstrated safe to protect your dog or cat from heartworm disease, fleas, and ear mites. Revolution is also used on dogs for the treatment or prevention of the American Dog Tick, and canine sarcoptic mange. For cats it is also used to treat or prevent hookworms, and roundworms. Revolution requires a prescription from your veterinarian.
: What are the possible side effects of Revolution?
The most common side effects include hair loss at the site of application with or without inflammation (redness, flaking) and gastrointestinal upset. See important safety information and full prescribing information, or speak to your vet for further information regarding possible side effects.
: How does Revolution work?
Just one dose a month applied at the base of the neck in front of the shoulder blades is all your pet needs for protection against fleas, heartworm disease and other parasites. No pills. No sticky sprays. No more hassling with multiple products.

After application, Revolution enters the bloodstream through the skin. Concentrations of Revolution in the blood and tissues prevent heartworm disease. Revolution selectively redistributes from the blood to the skin, where it provides protection against against common parasites.
: How can I decide which pest protection is best for my pet?
Parasites are an annoying fact of life for our pets. Parasites can cause a range of problems, from bothersome scratching to more serious medical issues, such as infections and dangerous or even deadly diseases. How dangerous these problems are depends on the type of parasite, the degree of infection or infestation, and your pet’s reaction to the parasite.

Some parasites that affect dogs and cats also pose a disease risk to humans. Talk to your veterinarian about preventing these parasites and reducing their risks to your dog or cat.
: How do I apply Revolution to my pet?
Revolution is a simple-to-apply, quick-drying, small-volume, monthly topical solution—so there’s no need to hassle with larger volume topicals or giving your pet a pill!
: What if I’m late giving a Revolution dose?
Give the missed dose as soon as soon as you remember, then one month later continue with monthly doses as usual. Do not give a double dose of the medication.
: What should I discuss with my veterinarian before using Revolution?
Tell your veterinarian if your pet has ever had an allergic reaction to the medication.
: What is the difference between Revolution and Revolution Plus?
Revolution Plus (selamectin and sarolaner topical solution) is for cats only. Revolution (selamectin) is for dogs and cats.

Revolution Plus adds to the spectrum of parasites covered for cats, by also protecting against ticks, and providing dual action against fleas and ear mites.

IMPORTANT SAFETY INFORMATION: See Prescribing Information. Do not use Revolution on sick, weak, or underweight animals. Use only on cats 8 weeks and older. Use only on dogs 6 weeks and older. Prior to administration, dogs should be tested for heartworms. In cats, side effects may include digestive upset and temporary hair loss at application site with possible inflammation. In people, Revolution may be irritating to skin and eyes. Wash hands after use.

Simparica Trio
Use with caution in dogs with a history of seizures. Simparica Trio contains sarolaner, a member of the isoxazoline class, which has been associated with neurologic adverse reactions including tremors, ataxia, and seizures in dogs with or without a history of neurologic disorders. The safe use of Simparica Trio has not been evaluated in breeding, pregnant, or lactating dogs. The most frequently reported adverse reactions in clinical trials were vomiting and diarrhea. See Prescribing Information.

Revolution Plus
The safe use of Revolution Plus has not been established in kittens less than 8 weeks old or in breeding, pregnant or lactating cats. Reported side effects in clinical trials included lethargy and anorexia. Use with caution in cats with a history of neurologic disorders. Sarolaner, one of the ingredients in Revolution Plus, is a member of the isoxazoline class, which has been associated with adverse reactions such as tremors, ataxia, and seizures. Reactions have occurred in cats with or without a history of neurologic disorders. In humans, Revolution Plus may be irritating to skin and eyes. See Prescribing Information.

*The American dog tick (Dermacenter variabilis)

References:

Cat Owners — Fleas. Companion Animal Parasite Council. Available at: http://www.petsandparasites.org/cat-owners/fleas/. Accessed September 2018.
Cat Owners — Ticks. Companion Animal Parasite Council. Available at: http://www.petsandparasites.org/cat-owners/ticks/. Accessed September 2018.
Companion Animal Parasite Council. Ticks. April 12, 2017. https://capcvet.org/guidelines/ticks. Accessed September 10, 2019.
CAPC: Otodectic Mite (Ear Mite). Available at https://www.capcvet.org/guidelines/otodectic-mite/; accessed April 14, 2022.
Atkins CE, DeFrancesco TC, Coats JR, Sidley JA, Keene BW. Heartworm infection in cats: 50 cases (1985-1997). J Am Vet Med Assoc. 2000;217(3):355-358.
Cat Owners — Heartworms. Companion Animal Parasite Council. Available at: http://www.petsandparasites.org/cat-owners/heartworms/. Accessed September 2018.
Heartworm in cats. American Heartworm Society. Available at https://www.heartwormsociety.org/heartworms-in-cats. Accessed June 2018.
Gastrointestinal parasites of cats. Cornell University College of Veterinary Medicine. Available at: https://www.vet.cornell.edu/departments-centers-and-institutes/cornell-feline-health-center/health-information/feline-health-topics/gastrointestinal-parasites-cats-brochure. Accessed June 2018.
Cat Owners — Roundworms. Companion Animal Parasite Council. Available at: http://www.petsandparasites.org/cat-owners/roundworms/. Accessed September 2018.
Cat Owners — Hookworms. Companion Animal Parasite Council. Available at: http://www.petsandparasites.org/cat-owners/hookworms/. Accessed September 2018.

ZPC-01862

The product information provided in this site is intended only for residents of the United States. The products discussed herein may not have marketing authorization or may have different product labeling in different countries. The animal health information contained herein is provided for educational purposes only and is not intended to replace discussions with an animal healthcare professional. All decisions regarding the care of a veterinary patient must be made with an animal healthcare professional, considering the unique characteristics of the patient.

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Protect Your Pet From Harmful Parasites with One Monthly Application